A negative blood type and von willebrand

Dogs having low plasma VWF:Ag (below 50%) are predicted at risk of transmitting or expressing the vWD trait. The Comparative Coagulation Laboratory reports each dog's result as %VWF:Ag compared to a 100% standard. This test measures the amount or concentration of VWF in a blood sample. Laboratory diagnosis of VWD is most often based on results of von Willebrand factor antigen assay (abbreviated VWF:Ag). These drugs include aspirin, sulfa-type antibiotics, and heparin. Affected dogs should not be given drugs that interfere with normal blood clotting mechanisms. Bleeding from minor injuries may be controlled using sutures, bandages or wound glue. Desmopressin acetate (DDAVP) can also be used to improve hemostasis in dogs with mild subtype (Type 1) VWD. Plasma products can be transfused pre-operatively to prevent surgical hemorrhage. Treatment of a severe bleeding episode requires transfusion of canine blood products. Severe bruising along incision line after Infections, endocrine disorders, and certain medications may exacerbate signs of bleeding in vWD-affected dogs.

Dewclaw removal and teething may cause excessive bleeding in vWD-affected pups. Uncontrollable bleeding may occur after surgery. Severe vWD causes spontaneous bleeding from the nose, mouth, and urinary, reproductive or intestinal tracts. Dogs may 'carry' the vWD trait without expressing a bleeding tendency. German Shorthaired Pointer, German Wirehaired PointerД¬hesapeake Bay Retriever, Dutch Kooiker, Scottish Terrier, Shetland SheepdogД«lue Heeler, Border Collie, Bull Terrier, Cocker Spaniel, Labrador Retriever, mixed breed, Pomeranian and othersД¬linical signs of vWD range from a mild to severe bleeding tendency. Characteristic biochemical and clinical findings have been described in a number of breeds with high prevalence and/or severe forms of vWD.ДЄiredale, Akita, Bernese Mountain Dog, Dachshund, Doberman Pinscher, German Shepherd, Golden Rertiever, Greyhound, Irish Wolfhound, Manchester Terrier, Schnauzer, Pembroke Welsh Corgi, Poodle, Shetland Sheepdog and others Within each breed a single form of vWD predominates. There are three variants or forms of vWD (types 1,2,3) defined by the quantity and structure of plasma von Willebrand factor (abbreviated vWF) in affected dogs. Von Willebrand disease is a distinct disorder, it is not hemophilia. This protein circulates in the blood stream and must be present at the site of blood vessel injury in order to control bleeding from that vessel. Von Willebrand Disease (abbreviated vWD) is an inherited bleeding disorder caused by lack of von Willebrand factor protein (vWF).

A negative blood type and von willebrand